Libertate şi condiţionare genetică în persoana umană

Diac. dr. Adrian Sorin Mihalache     Duminică, 27 octombrie 2013 În cuprinsul vieţii spirituale ve­dem, în toată splendoarea, pu­terea omului duhovnicesc asupra slăbiciunilor firii, asu­pra lumii căzute şi a ispitelor ei. Prin viaţa lor, sfinţii şi martirii, cuvioşii şi asceţii dau mărturie, peste veacuri, de puterea pe care orice om cu viaţă înduhovnicită o poate…

Gregor Johann Mendel

BRNO TODAY: Biography Gregor Mendel was born into an ethnic German family in Heinzendorf bei Odrau, Austrian Silesia, Austrian Empire (now Hynčice, Czech Republic). He was the son of Anton and Rosine (Schwirtlich) Mendel, and had one older sister (Veronica) and one younger (Theresia). They lived and worked on a farm which had been owned…

Uniparental Disomy (UPD)

Review Cytogenetic contribution to uniparental disomy (UPD) Thomas  Liehr Jena University Hospital, Institute of Human Genetics and Anthropology, Kollegiengasse 10, D-07743 Jena, Germany Uniparental disomy (UPD) is often considered as an event to be characterized exclusively by molecular genetic or epigenetic approaches. This review shows that at least one third of UPD cases emerge in connection with…

Inheritance patterns

Inheritance patterns trace the transmission of genetically encoded traits, conditions or diseases to offspring.  There are several modes of inheritance: Single Gene or Mendelian Multifactorial Mitochondrial Note: These explanations use pedigrees to illustrate inheritance patterns.  If you are unfamiliar with pedigrees, see Pedigrees for an explanation of the symbols. Single Gene Inheritance Genetic conditions caused…

Autosomal recessive inheritance pattern

  To have an autosomal recessive disorder, you inherit two mutated genes, one from each parent. These disorders are usually passed on by two carriers. Their health is rarely affected, but they have one mutated gene (recessive gene) and one normal gene (dominant gene) for the condition. Two carriers have a 25 percent chance of…

Penetrance and expressivity

Classically, the genetic basis of the dependence of one gene on another is deduced from clear genetic ratios. However, only a small proportion of genes in the genome lend themselves to such analysis. One important property is that the mutation not exhibit decreased viability or fertility relative to wild type so that the frequency of…

Mendelian Genetics: Patterns of Inheritance and Single-Gene Disorders

By: Heidi Chial, Ph.D. (Write Science Right) © 2008 Nature Education Citation: Chial, H. (2008) Mendelian genetics: Patterns of inheritance and single-gene disorders. Nature Education 1(1) What can Gregor Mendel’s pea plants tell us about human disease? Single gene disorders, like Huntington’s disease and cystic fibrosis, actually follow Mendelian inheritance patterns. Mendel’s studies of inheritance patterns in pea plants are a solid foundation for our current…